Cheng AA, Li W, Hernandez LLTranscriptomic analysis investigating the interaction between peripheral serotonin and high fat diet feeding on mammary gene expression in mid-lactation mice. 2020.  Physiol Genomics. 52(1):47-55. doi: 10.1152/physiolgenomics.00073.2019. [Epub ahead of print] PubMed PMID: 31814535.

Deer EM, Welch B, Hernandez LL, Seeley RJ, and Grayson BE. 2020. Nutrient and hormone composition of milk is altered in rodent dams post-bariatric surgery. J. Dev. Orig. Health Dis. 11(1):71-77. Doi: 10.1017/S2040174419000424. Epub. Ahead of print. PMID:31397254. PMCID:PMC6934892.

Hernandez-Castellano LE, Hernandez LL, and Bruckmaier RM. 2020. Review: endocrine pathways to regulate calcium homeostasis around parturition and the prevention of hypocalcemia in periparturient dairy cows. Animal. 14(2):330-338. PMID: 31337460.

Zhang X, Wang X, Yin H, Zhang L, Feng A, Zhang QX, Lin Y, Bao B, Hernandez LL, Shi GP, and Liu J. 2019.  Functional inactivation of mast cells enhances subcutaneous adipose tissue browning in mice. Cell Rep. 28(3):792-803 e4. PMID:31315055. PMCID:PMC6662660.

Carvalho PD, Santos VG, Fricke HP, Hernandez LL, Fricke PM. 2019. Effect of manipulating progesterone before times artificial insemination on reproductive performance and endocrine outcomes in high-producing multiparous Holstein cows.  J. Dairy Sci. 102(3):7509-7521.  PMID: 31155251.

Kuehnl JM, Connelly MK, Dzidic A, Lauber M, Fricker HP, Klister M, Olstad E, Balbach M, Timlin E, Pszczolkowski V, Crump PM, Reinemann DJ, Hernandez LL.  2019.  The effect of  incomplete milking and increased milking frequency on milk production rate and milk composition.  J. Animal Sci. Apr 15. Epub ahead of print.  PMID: 30982896.

Niles AM, Fricke HP, Carvalho PD, Wiltbank MC, Hernandez LL, Fricke PM.  2019.  Effect of treatment with human chorionic gonadotropin 7 days after artificial insemination or at the time of embryo transfer on reproductive outcomes in nulliparous Holstein heifers.  J. Dairy Sci. 102(3):2593-2606.  PMID: 30692012.

Kessler EC, Wall SK, Hernandez LL, Gross JJ, Bruckmaier RM.  2019.  Short communication: mammary gland tight junction permeability after parturition is greater in dairy cows with elevated circulating serotonin concentrations.  J. Dairy Sci. 102(2):1768-1774.  PMID: 30580948.

Metzger SA, Hernandez LL, Skarlupka JH, Walker TM, Suen G, Ruegg PL.  2018.  A cohort study of the milk microbiota and inflamed bovine mammary glands from dryoff through 150 days in milk.  Front. Vet Sci.Oct 9;5:247. eColletion 2018. PMID: 30356776.

Weaver SR, Fricke HP, Xie C, Aiello RJ, Charles JF, Hernandez LL.  2018.  Peripartum dietary supplementation of a small molecule inhibitor of tryptophan hydroxylase 1 compromises infant, but no maternal, bone.  Am. J. Endocrinol. Metab.  Oct 23. Epub ahead of print.  PMID: 30351987.

Cheng AA, Hernandez LL,Li W.  2018. The effect of high-fat diet feeding and associated transcriptome changes in the peak lactation mammary gland in C57BL/6 dams.  Physiol. Genomics. Epub. Ahead of print.  PMID: 30339477.

Amundson LA, AD Rowson, PM Crump, AP Prichard, AA Cheng, CE Wimmler, M Klister, SR Weaver, SS Bascom, DE Nuzback, KP Zanzalari, LL Hernandez.  2018.  Effect of induced hypocalcemia in nonlactating, nonpregnant Holstein cows fed negative DCAD with low, medium, or high concentrations of calcium.  J. Anim. Sci.Oct 12. Epub ahead of print. PMID: 30321366.

Metzger SA, LL Hernandez, G Suen, PL Ruegg. 2018. Understanding the milk microbiota. Vet. Clin. North Am. Food Anim. Pract.  34(3):427-438.  PMID: 30316501.

Kessler EC, SK Wall, LL Hernandez, RM Bruckmaier, and JJ Gross.  2018.  Short Communication: Circulating serotonin is related to the metabolic status and lactational performance at the onset of lactation in dairy cows.  J. Dairy Sci.Sep 19. Epub ahead of print. PMID:30243629.

Amundson L. A., L. L. Hernandez, T. D. Crenshaw.  2018.  Gene expression of matrix metalloproteinase 9 (MMP9), matrix metalloprteinase (MMP13), vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF23) in femur and vertebra tissues of they hypovitaminosis D kyphotic pig model.  Br. J. Nutr. Epub ahead of print. PMID: 29991364.

Weaver S. R., H. P. Fricke, C. Xie, R. J. Lipinski, C. M. Vezina, J. F. Charles, L. L. Hernandez. 2018.  Peripartum Fluoxetine reduces maternal trabecular bone post-weaning and elevated mammary gland serotonin and PTHrP.  Endocrinology. 159(8):2850-2862. PMID: 29893816.

Penry J. F., P. M. Crump, L. L. Hernandez, D. J. Reinemann. 2018. Association of quarter milking measurements and cow-level factors in an automatic milking system.  J. Dairy Sci. May 9. Epub ahead of print. PMID: 29753475.

Hernandez L. L. 2018. ADSA Foundation Scholar Award: A role for serotonin in lactation physiology-Where do we go from here?  J. Dairy Sci. 101(7):5671-5678.  PMID:29705428.

Metzger S. A., L. L. Hernandez, J. H. Skarlupka, G. Suen, T. M. Walker, P. L. Ruegg.  2018.  Influence of sampling technique and bedding type on the milk microbiota: Results of a pilot study.  J. Dairy. Sci. 101(7):6346-6356.  PMID:29680645.

Slater C. J., E. L. Endres, S. R. Weaver, A. A. Cheng, M. R. Lauber, S. F. Endres, E. Olstad, A. DeBruin,  P. M. Crump, E. Block, L. L. Hernandez.  2018.  Interaction of 5-hydroxy-l-trypophan and negative dietary cation-anion difference on calcium homeostasis in multiparous permpartum dairy cows.  J. Dairy Sci. 101(6):5486-5501.  PMID:29605319.

Weaver S. R., L. L. Hernandez.  2018.  Could use of selective serotonin reuptake inhibitors lactation cause persistent effects on maternal bone?  J. Mammary Gland Biol. Neoplasia. 23(1-2):5-25.  PMID: 29603039.

Penry J.F., P.M. Crump, L.L. Hernandez, D.J. Reinemann. Association of milking interval and milk production rate in an automatic milking system. 2018.  J. Dairy Sci. 101(3):2563-2578. PMID:29153525.

Hernandez L. L. 2017.  Triennial Lactation Symposium/BOLFA: Serotonin and the regulation of calcium transport in dairy cows.  J. Anim. Sci. 95(12):5711-5719.  PMID: 29293773.

Rodney R.M., N. Martinez, E. Block, L.L. Hernandez, P. Celi, C.D. Nelson, J.E.P. Santos, and I.J. Lean.  Effects of prepartum dietary cation-anion difference and source of vitamin D on dairy cows: vitamin D, mineral and bone metabolism.  J. Dairy Sci.  101(3): 2519-2543. PMID: 29274979.

Martinez N., R.M. Rodney, E. Block, L.L. Hernandez, C.D. Nelson, I.J. lean, and J.E.P. Santos.  Effects of prepartum dietary cation-anion difference and source of vitamin D on dairy cows: health and reproductive responses.  J. Dairy Sci. 101(3): 2563-2578.  29274983.

Martinez N., R.M. Rodney, E. Block, L.L. Hernandez, C.D. Nelson, I.J. Lean, and J.E.P. Santos.  Effects of prepartum dietary cation-anion difference and source of vitamin D on dairy cows: lactation performance and energy metabolism. J. Dairy Sci. 101(3): 2544-2562. PMID: 29153525.

Hernandez-Castellano L.E., R. Ozcelik, L.L. Hernandez, and R.M. Bruckmaier. 2018. Short communication: Supplementation of colostrum and milk with 5-hydroxy-L-tryptophan affects immune factors in newborn calves without impact on growth performance.  J. Dairy Sci. 101(1):794-800. PMID: 29102139.

Hernandez L.L. Serotonin and the regulation of calcium transport in dairy cows.  2017. J. Anim Sci.  95(12):5711-5719. PMID:29293773.

Weaver S.R., N.J. Jury, K.A. Gregerson, N.D. Horseman, L.L. Hernandez. (2017). Characterization of mammary specific disruptions for Tph1 and Lrp5 during murine lactation. Sci. Rep. 9(7):15155. PMID: 29123193.

Weaver, S. R., A. S. Prichard, N. L. Maerz, A. P. Prichard, E. L. Endres, L. E. Hernandez-Castellano, M. S. Akins, R. M. Bruckmaier, and L. L. Hernandez.  2017.  Elevating serotonin pre-partum alters the Holstein dairy cow adaptation to lactation.  PLoS One. 12(9):e0184939.  PMID: 28922379.

Amundson, L. A., L. L. Hernandez, and T. D. Crenshaw.  2017.  Serum and tissue 25-OH vitamin D3 concentrations do no predict bone abnormalities and molecular markers of vitamin D metabolism in the hypovitaminosis D kyphotic pig model.  Br. J. Nutr. 118(1):30-40.  PMID: 28745259.

Hernandez-Castellano, L. E., L. L. Hernandez, H. Sauerwein, and R. M. Bruckmaier.  2017.  Endocrine and metabolic changes in transition dairy cows are affected by permpartum infusions of a serotonin precursor.  J. Dairy Sci. 100:5050-5057. PMID: 28434742.

Carvalho, P. D., C. C. Consentini, S. R. Weaver, R. V. Barleta, L. L. Hernandez, and P. M. Fricke. 2017.  Temporarily decreasing progesterone after timed artificial insemination decreased expression of interferon-tau stimulated gene 15 (ISG15) in blood leukocytes, serum pregnancy-specific protein B concentrations, and embryo size in lactating Holstein cows.  J. Dairy Sci. 100:3233-3242.  PMID:28189320

Hernandez-Castellano, L. E., L. L. Hernandez, S. R. Weaver, and R. M. Bruckmaier.  2017.  Increased serum serotonin improves parturient calcium homeostasis in cows.  J. Dairy Sci. 100:1580-1587.  PMID:27988124.

Penry, J. F., E. L. Endres, B. de Bruijn, A. Klenihans, P. M. Crump, D. J. Reinemann, L. L. Hernandez.  2017.  Effect of incomplete milking on milk production rate and composition with 2 daily milkings.  J. Dairy Sci. 100:1535-1540.  PMID: 27939533.

Weaver, S. R., J. C. Bohrer, A. S. Prichard, P. K. Perez, L. J. Streckenbach, J. M. Olson, M. E. Cook, and L. L. Hernandez.  2016  Serotonin deficiency rescues lactation on day 1 in mice fed a high fat diet.  PLoS One. 11(9):e0162432.  PMID: 27603698.

Amundson L. A., L. L. Hernandez, J. Laporta, T. D. Crenshaw.  2016.  Maternal vitamin D carry-over alters offspring growth, skeletal mineralization and tissue mRNA expression of genes related to vitamin D, calcium, and phosphorous homeostasis in swine.  Br. J. Nutr. Aug 2. 2:1-14.  PMID:27480125.

The article below has press releases at the following links:

Weaver, S. R., A. P. Prichard, E. L. Endres, S. A. Newhouse, T. L. Peters, P. M. Crump, M. S. Akins, T. D. Crenshaw, R. M. Bruckmaier, and L. L. Hernandez. 2016.  Elevation of circulating serotonin improves calcium dynamics in the permpartum dairy cow.  J. Endocrinol. 230(1):105-123.  PMID: 27390301

Weaver, S. R., J. Laporta, S. A. Moore, and L. L. Hernandez. 2016. Serotonin and calcium homeostasis during the transition period.  Domest. Anim. Endocrinol. 56 Suppl:S147-154. PMID: 27345312

Weaver, S. R., and L. L. Hernandez.  2016. Autocrine-paracrine regulation of the mammary gland. Epub. ahead of print.  J. Dairy Sci. 99(1):842-853. PMID:26299162

Weaver, S. R., C. M. Cronick, A. P. Prichard, J. Laporta, N. J. Benevenga, and L. L. Hernandez.  2015.  The use of the RatLoft decreases pup mortality in lactating mice.  Lab. Anim. Nov 14 ouuL9923677215617388.  PMID: 26568578.

Laporta, J., F. Penagaricano, and L. L. Hernandez.  2015.  Transcriptomic analysis of the mouse mammary gland reveals new insights for the role of serotonin in lactation.  PLoS One.   10(10):e0140425.  PMID: 26470019.

Keil K.P., H. M. Altmann, L. L. Abler, L.L. Hernandez, and C. M. Vezina.  2015.  Histone acetylation regulates prostate ductal morphogenesis through a BMP dependent mechanism.  Dev. Dyn.  Epub ahead of print.  PMID: 26283270.

Laporta J., S.A.E. Moore, S.R. Weaver, C.M. Cronick, M. Olsen, A.P. Prichard, B.P. Schnell, T.D. Crenshaw, F. Penagaricano, R.M. Bruckmaier, and L.L. Hernandez.  2015. Increasing serotonin concentrations alters calcium and energy metabolism in dairy cows.  J. Endocrinol. 226(1):43-55.

The article below was Editor’s Choice in the Physiology and Management Section of the Journal of Dairy Science June Issue:

Moore, S. A. E., J. Laporta, T.D. Crenshaw, and L. L. Hernandez.  2015.  Patterns of circulating serotonin (5-HT) and related metabolites in multiparous dairy cows in the permpartum period.  J. Dairy Sci. Mar. 28 Epub ahead of print.  PMID:25828664.

Pai, V. P., Hernandez L. L., Stull M. A., and Horseman N.D. 2015.  They type 7 receptor, 5-HT7, is essential in the mammary gland for regulation of mammary epithelial structure and function.  Biomed. Res. Int. 2015:364746.  PMID:25664318.

Laporta, J., and L. L. Hernandez.  2015.  Serotonin receptor expression is dynamic in the liver during the transition period in Holstein dairy cows.  Dom. Anim. Endocrinol. 51:65-73PMID: 25528206.

The manuscript below has been featured on the Molecular Endocrinology Website for the month of November, please take a look for more information! (  Also, an article on Medpage was written entitled “Does Breast Feeding Drain Women of Calcium?” featuring our research at the following link:

Laporta, J., K. P. Keil, S. R. Weaver, C. M. Cronick, A. P. Prichard, T. D. Crenshaw, G. W. Heyne, C. M. Vezina, R. J. Lipinski, and L. L. Hernandez. 2014.  Serotonin regulates calcium homeostasis in lactation by epigenetic activation of Hedgehog signaling.  Mol. Endocrinol. 28(11):1866-1874.  PMID: 25192038.

Laporta, J., K. P. Keil, C. M. Vezina, and L. L. Hernandez.  2014.  Peripheral serotonin regulates maternal calcium trafficking in mammary epithelial cells during lactation in mice.  PLoS One. 9(10):e110190.  PMID: 25299122.

Laporta, J., J. J. Gross, T. D. Crenshaw, R. M. Bruckmaier, and L. L. Hernandez.  2014. Short communication:  Timing of first milking affects serotonin (5-HT) concentrations. J. Dairy Sci. 97(5): 2944-2948. PMID:24612806.

Keil, K. P., L. L. Abler, V. Mehta, H. M. Altmann, J. Laporta, E. H. Plisch, M. Suresh, L. L. Hernandez and C. M. Vezina.  2014.  DNA methylation of E-cadherin is a priming mechanism for prostate development.  Dev. Biol.  387(2):142-153.  PMID: 24503032.

Marshall, A. M., L. L. Hernandez, and N. D. Horseman.  2014.  Serotonin and serotonin transport in the regulation of lactation.  J. Mammary Gland Biol. Neoplasia. 19(1):139-146. PMID:24136337.

Horseman N. D., Hernandez L. L.  2014. New Concepts of Breast Cell Communication to Bone.  Trends Endocrinol. Metab.  25(1):34-41.  PMID: 24055165

Laporta, J., S. A. Moore, M. W. Peters, T. L. Peters, and L. L. Hernandez.  2013.  Short communication: Circulating serotonin (5-HT) concentrations on day 1 of lactation as a potential predictor of transition-related disorders.  J. Dairy Sci. 96(8):5146-5150.  PMID: 23746592.

Laporta, J., T. L. Peters, K. E. Merriman, C. M. Vezina, and L. L. Hernandez.  2013.  Serotonin (5-HT) affects expression of liver metabolic enzymes and mammary gland glucose transporters during the transition from pregnancy to lactation.  PLoS One.  8(2): e57847.  PMID:  23469086

Laporta, J., T. L. Peters, S. R. Weaver, K. E. Merriman and L. L. Hernandez.  2013.  Feeding 5-hydroxy-L-tryptophan during the transition from pregnancy to lactation increases calcium mobilization from bone in rats.  Dom. Anim. Endocrinol.  44(4):176-184.  PMID:  23733710

Collier R. J., L. L. Hernandez, N.D. Horseman.  2012.  Serotonin as a homeostatic regulator of lactation.  Domest. Anim. Endocrinol.  Apr 19 [Epub ahead of print].

Hernandez, L.L., K.A. Gregerson, and N.D. Horseman.  2012.  Serotonin is an upstream regulator in the breast-to-bone axis.  Am. J. Physiol. Endocrinol. Metab.  302:E1009-E1015.

Hernandez, L. L., B. E. Grayson, E. Yadav, R. J. Seeley, and N. D. Horseman.  2012.  High Fat Diet Alters Lactation Outcomes: Possible Involvement of Inflammatory and Serotonergic Pathways.  PLoS One.  7(3):e32598. Epub Mar 5.

Babcock, G., L. Hernandez, E. Yadav, S. Schwemberger, and A. Dugan.  2011.  The burn wound inflammatory response is influenced by midazolam.  Mar 12: Epub ahead of print.  Inflammation.  PMID: 21400122

Hernandez, L.L., J. L. Collier, A.V. Vomachka, R. J. Collier, and N.D. Horseman.  2011.  Suppression of lactation and acceleration of involution in the bovine by a selective serotonin reuptake inhibitior (SSRI).  J. Endocrinol.  209:45-54.

Yates, D.T., G.L. Strosser, P.L. Black, R.A. Halasheh, L.M. Lankford, L.L. Hernandez, C.A. Loest, and T.T. Ross.  2010.  Technical Note: Effects of rumen passage on fluoxetine bioavailability in serum and effects of fluoxetine on serum prolactin concentration and demeanor in ewes. Jul 9. Epub. Ahead of print.  J. Anim. Sci.

Marshall, A.M., L.A. Nomsen-Rivers, L.L. Hernandez, K.G. Dewey, C.J. Chantry, K.A. Gregerson and N.D. Horseman.  2010.  Intrinsic Serotonin Turnover Affects Mammary Epithelial Tight Junctions, and Modulates Stage II Lactogenesis and Involution. J. Clin. Endocrinol. Metab. 95(2). 837-846.

Pai, V., A.M. Marshall, L.L. Hernandez, A.R. Buckley, and N.D. Horseman, 2009.  Phenotypic Heterogeneity of the Serotonin System in Human Breast Cancer.  Breast Cancer Res.  11(6):R81.

Hernandez, L.L., S.W. Limesand, J.L. Collier, N.D. Horseman, and R.J. Collier.  2009.  The Bovine Mammary Gland Expresses Multiple Functional Isoforms of Serotonin Receptors.  J. Endocrinol. 203:123-131.

Hernandez, L.L, C.M. Stiening, J.B. Wheelock, L.H. Baumgard, A.M. Parkhurst, and R.J. Collier.  2008.  Evaluation of Serotonin as a Feedback Inhibitor of Lactation in the Bovine. J. Dairy Sci.  91: 1834-1844